Mismatch negativity and low frequency oscillations in schizophrenia families

作者：Hong L Elliot^*; Moran Lauren V; Du Xiaoming; O'Donnell Patricio; Summerfelt Ann

来源：Clinical Neurophysiology, 2012, 123(10): 1980-1988.

DOI：10.1016/j.clinph.2012.03.011

• MMN
• Theta
• Alpha
• Oscillations
• Single trial
• Schizophrenia
• Genetics
• Heritability

Objective: Theta-alpha range oscillations have been associated with MMN in healthy controls. Our previous studies showed that theta-alpha activities are highly heritable in schizophrenia patients' families. We aimed to test the hypothesis that theta-alpha activities may contribute to MMN in schizophrenia patients and their family members.
Methods: We compared MMN and single trial oscillations during MMN in 95 patients, 75 first-degree relatives, 87 controls, and 34 community subjects with schizophrenia spectrum personality (SSP) traits.
Results: We found that (1) MMN was reduced in patients (p < 0.001) and SSP subjects (p = 0.047) but not in relatives (p = 0.42); (2) there were augmented 1-20 Hz oscillations in patients (p = 0.02 to < 0.001) during standard and deviant stimuli; (3) theta-alpha (5-12 Hz) oscillations had the strongest correlation to MMN in controls and relatives (Delta R-2 = 21.4-23.9%, all p < 0.001), while delta (< 5 Hz) showed the strongest correlation to MMN in schizophrenia and SSP trait subjects; and, (4) MMN (h(2) = 0.56, p = 0.002) and theta-alpha (h(2) = 0.55, p = 0.004) were heritable traits.
Conclusions: Low frequency oscillations have a robust relationship with MMN and the relationship appears altered by schizophrenia; and schizophrenia patients showed augmented low frequency activities during the MMN paradigm.
Significance: The results encourage investigation of low frequency oscillations to elucidate the neurophysiological pathology underlying MMN abnormalities in schizophrenia.

• 出版日期2012-10