摘要
ANTIFUNGAL GLYCOALKALOIDS, FLAVONOIDS AND OTHER CHEMICAL CONSTITUENTS OF Solanum asperum Rich (Solanaceae). Two glycoalkaloids: solamargine and solasonine; three flavonoids: tiliroside, 7-O-alpha-L-ramnopyranosyl-kaempferol and 3-O-[beta-D-glucopyranosyl-(1 -> 6)-alpha-L-ramnopyranosyl]-7-O-alpha-L-ramnopyranosyl-kaempferol, in addition to the tripeptide Leu-Ile-Val, the aminoacid proline and the eicosanoic acid were isolated from Solanum asperum (Solanaceae). The structures of all compounds were determined by interpretation of their spectra (IR, MS, H-1 and C-13 NMR) and comparison with the literature data. All compounds, except the glycoalkaloids, are being reported for the first time for S. asperum. Solasonine showed strong activity (MIC <0.24 mu g/mL) against four filamentous fungi species of the genera Microsporum and Trichophyton.
- 出版日期2011