A novel compact mass detection platform for the open access (OA) environment in drug discovery and early development

作者：Gao Junling; Ceglia Scott S^*; Jones Michael D^*; Simeone Jennifer; Van Antwerp John; Zhang Li Kang; Ross Charles W III; Helmy Roy

来源：Journal of Pharmaceutical and Biomedical Analysis, 2016, 122: 1-8.

DOI：10.1016/j.jpba.2016.01.017

• Compact mass detector
• Open-access
• UPLC-MS
• Process
• Development
• Drug discovery

A new 'compact mass detector' co-developed with an instrument manufacturer (Waters Corporation) as an interface for liquid chromatography (LC), specifically Ultra-high performance LC (R) (UPLC (R) or UHPLC) analysis was evaluated as a potential new Open Access (OA) LC-MS platform in the Drug Discovery and Early Development space. This new compact mass detector based platform was envisioned to provide increased reliability and speed while exhibiting significant cost, noise, and footprint reductions. The new detector was evaluated in batch mode (typically 1-3 samples per run) to monitor reactions and check purity, as well as in High Throughput Screening (HTS) mode to run 24, 48, and 96 well plates. The latter workflows focused on screening catalysis conditions, process optimization, and library work. The objective of this investigation was to assess the performance, reliability, and flexibility of the compact mass detector in the OA setting for a variety of applications. The compact mass detector results were compared to those obtained by current OA LC-MS systems, and the capabilities and benefits of the compact mass detector in the open access setting for chemists in the drug discovery and development space are demonstrated.

• 出版日期2016-4-15