An Elegant Synthesis of a New Class of 1-(Substituted)-1H-1,2,3-triazol-4-yl)methyl)diphenylphosphineoxides by Microwave Irradiation

作者：Chinthaparthi Radha Rani; Gangireddy Chandra Sekhar Reddy; Kandula Madhu Kumar Reddy; Balam Satheesh Krishna; Cirandur Suresh Reddy^*

来源：Journal of Heterocyclic Chemistry, 2015, 52(6): 1876-1882.

DOI：10.1002/jhet.2297

A simple and efficient one-pot microwave-assisted click formation of 1-(substituted)-1H-1,2,3-triazol-4-yl)methyl)diphenylphosphineoxide derivatives via Huisgen regioselective [3+2]-cycloaddition of an in situ generated organic azides and diphenyl(prop-2-yn-1-yl)phosphine oxide in highly polar DMSO-H2O medium. This synthetic protocol is mild, requires shorter reaction time, and afforded products in excellent yields with high regioselectivity.

• 出版日期2015-11