Direct-type vinylogous Mukaiyama-Michael addition reactions involving pyrrolinone donors

作者：Sartori Andrea; Curti Claudio; Battistini Lucia; Burreddu Paola; Rassu Gloria; Pelosi Giorgio; Casiraghi Giovanni; Zanardi Franca^*

来源：Tetrahedron, 2008, 64(51): 11697-11705.

DOI：10.1016/j.tet.2008.10.007

• Vinylogous Michael reaction
• 1,4-Addition reaction
• Pyrrolin-2-ones
• 4-Methoxytetramates

The direct Mukaiyama-Michael addition of vinylogous tetramate donors to a number of different Michael acceptors has been easily executed, by employing the TMSOTf/Et(3)N Mixture as soft Lewis acid/base promoter agent. Richly functionalized, highly manipulable gamma-substituted pyrrolinone products were practically synthesized in acceptable to excellent yields, and with diastereoselectivities heavily relying upon the substituent at the nitrogen atom of the pyrrolinone donor.

• 出版日期2008-12-15