High prevalence of hepatitis B and hepatitis C virus infections in Korean patients with hematopoietic malignancies

作者：Kang Jun; Cho Jeong Hyun; Suh Cheol Won; Lee Dae Ho; Oh Heung Bum; Sohn Yong Hak; Chi Hyun Sook; Park Chan Jeong; Jang Sung Soo; Lee Kyoo Hyung; Lee Je Hwan; Lee Jung Hee; Lee Sang Wook; Chung Young Hwa; Kim Tae Hyup; Shin Hai Rim; Huh Jooryung^*

来源：Annals of Hematology, 2011, 90(2): 159-164.

DOI：10.1007/s00277-010-1055-5

• Case-control study
• Hepatitis B virus
• Hepatitis C virus
• Hematopoietic malignancy

We performed a large case-control study (3,932 cases, 15,562 controls) to investigate the association of hepatitis B virus (HBV) and hepatitis C virus (HCV) with hematopoietic malignancies in Korea, where HBV is endemic. HBV was present in 636 control patients (4.1%), 333 lymphoma patients (12.4%), and 75 leukemia patients (6.0%). HCV infection was present in 173 control patients (1.1%), 76 lymphoma patients (2.8%), and 18 leukemia patients (1.4%). Co-infection of HBV and HCV was present in one (0.007%) control patient, seven lymphoma patients (0.3%), and one leukemia patient (0.08%). HBV infection was associated with increased risks for most subtypes of B and T/NK-cell lymphomas, Hodgkin's lymphoma, and acute myeloid leukemia. HCV infection was associated with increased risks for diffuse large B cell lymphoma, extranodal marginal zone B cell lymphoma, peripheral T cell lymphoma, and acute lymphoid leukemia B cell early pre-B type. HBV seems to have a more important role than HCV in the pathogenesis of specific hematologic malignancies in Korea.

• 出版日期2011-2