An Efficient One-Pot Strategy for the Synthesis of Triazole-Fused 1,4-Benzodiazepinones from N-Substituted 2-Azidobenzamides

作者：Majumdar K C^*; Ganai Sintu

来源：Synthesis, 2013, 45(18): 2619-2625.

DOI：10.1055/s-0033-1339346

• fused triazole
• azide-alkyne cycloaddition
• 1
• 4-benzodiazepinones
• N-substituted 2-azidobenzamides
• catalyst-free

A catalyst-free, one-pot strategy for the synthesis of 1,2,3-triazole-fused 1,4-benzodiazepinone derivatives from N-substituted 2-azidobenzamides and propargyl bromide, in the presence of a base, is reported. The products are formed in good to excellent yields via N-alkylation followed by a 1,3-dipolar cycloaddition.

• 出版日期2013-9-17