Association of midlife lipids with 20-year cognitive change: A cohort study

作者：Power Melinda C; Rawlings Andreea; Sharrett A Richey; Bandeen Roche Karen; Coresh Josef; Ballantyne Christie M; Pokharel Yashashwi; Michos Erin D; Penman Alan; Alonso Alvaro; Knopman David; Mosley Thomas H; Gottesman Rebecca F

来源：Alzheimer's and Dementia, 2018, 14(2): 167-177.

DOI：10.1016/j.jalz.2017.07.757

• Lipids
• Cognition
• Dementia
• Epidemiology
• Cohort
• Longitudinal
• Cognitive decline
• Cognitive change
• Cholesterol

Introduction: Existing studies predominantly consider the association of late-life lipid levels and subsequent cognitive change. However, midlife rather than late-life risk factors are often most relevant to cognitive health.
Methods: We quantified the association between measured serum lipids in midlife and subsequent 20-year change in performance on three cognitive tests in 13,997 participants of the Atherosclerosis Risk in Communities study.
Results: Elevated total cholesterol, low-density lipoprotein cholesterol, and triglycerides were associated with greater 20-year decline on a test of executive function, sustained attention, and processing speed. Higher total cholesterol and triglycerides were also associated with greater 20-year decline in memory scores and a measure summarizing performance on all three tests. High-density lipoprotein cholesterol was not associated with cognitive change. Results were materially unchanged in sensitivity analyses addressing informative missingness.
Discussion: Elevated total cholesterol, low-density lipoprotein cholesterol, and triglycerides in midlife were associated with greater 20-year cognitive decline.

• 出版日期2018-2