A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability

作者：Flourakis Matthieu; Kula Eversole Elzbieta; Hutchison Alan L; Han Tae Hee; Aranda Kimberly; Moose Devon L; White Kevin P; Dinner Aaron R; Lear Bridget C; Ren Dejian; Diekman Casey O; Raman Indira M; Allada Ravi^*

来源：Cell, 2015, 162(4): 836-848.

DOI：10.1016/j.cell.2015.07.036

Circadian clocks regulate membrane excitability in master pacemaker neurons to control daily rhythms of sleep and wake. Here, we find that two distinctly timed electrical drives collaborate to impose rhythmicity on Drosophila clock neurons. In the morning, a voltage-independent sodium conductance via the NA/NALCN ion channel depolarizes these neurons. This current is driven by the rhythmic expression of NCA localization factor-1, linking the molecular clock to ion channel function. In the evening, basal potassium currents peak to silence clock neurons. Remarkably, daily antiphase cycles of sodium and potassium currents also drive mouse clock neuron rhythms. Thus, we reveal an evolutionarily ancient strategy for the neural mechanisms that govern daily sleep and wake.

• 出版日期2015-8-13
• 单位西北大学