Normal differentiation and functions of mouse dendritic cells derived from RAG-deficient bone marrow progenitors

作者：Faure M^*; Villiers CL; Marche PN

来源：Cellular Immunology, 2004, 228(1): 8-14.

DOI：10.1016/j.cellimm.2004.04.002

• dendritic cells
• progenitors
• cellular differentiation
• T lymphocytes

Dendritic cells (DC) mature upon infectious agent detection to elicit immune responses. It has been suggested that T cells influence peripheral DC function. However, it is not known if lymphocytes influence DC progenitors. Therefore, we determined the ability of bone marrow progenitors from T and B cell-deficient mice to generate functional DC. We report that bone marrow-derived DC from RAG-2(-/-) mice differentiate and proliferate normally. Moreover, such generated DC efficiently internalize particles, mature in response to various Toll-like receptor engagement, and activate allogenic T cells. This work strongly supports that early signals delivered during DC ontogeny by mature lymphocytes do not influence the functional differentiation of DC progenitors.

• 出版日期2004-3