A New Lanostanoid from Ganoderma lucidum

作者：Li, Peng^*; Shen, Cui-E; Nan, Ting-Ting; Xu, Jian-Hua

来源：Chemistry of Natural Compounds, 2016, 52(1): 71-73.

DOI：10.1007/s10600-016-1549-z

• Ganoderma lucidum
• lanostanoid
• cytotoxic activity

Phytochemical studies on the ethyl acetate extract of the fruiting body of Ganoderma lucidum afforded a new lanostanoid named 24(S),26-dihydroxy-5 alpha-lanosta-7,9,25-trien-3-one (1), along with two known compounds, ganoderic acid DM (2) and 5 alpha-lanosta-7,9(11),24-triene-15 alpha,26-dihydroxy-3-one (3). Their structures were established on the basis of spectroscopic analysis and chemical evidence. The cytotoxicity of the isolated compounds was evaluated in vitro against three human cancer cell lines (HCT-116, KB, and OE-19). Compound 3 showed moderate cytotoxic activity.

• 出版日期2016-1
• 单位福建医科大学