Novel method for screening of enteric film coatings properties with magnetic resonance imaging

作者：Dorozynski Przemyslaw^*; Jamroz Witold; Niwinski Krzysztof; Kurek Mateusz; Weglarz Wladyslaw P; Jachowicz Renata; Kulinowski Piotr

来源：International Journal of Pharmaceutics, 2013, 456(2): 569-571.

DOI：10.1016/j.ijpharm.2013.08.004

• Shellac
• Enteric coating
• Mini-tablets
• Delayed release
• Magnetic resonance imaging (MRI)
• Ultra-short echo time imaging (UTE)

The aim of the study is to present the concept of novel method for fast screening of enteric coating compositions properties without the need of preparation of tablets batches for fluid bed coating. Proposed method involves evaluation of enteric coated model tablets in specially designed testing cell with application of MRI technique. The results obtained in the testing cell were compared with results of dissolution studies of mini-tablets coated in fluid bed apparatus. The method could be useful in early stage of formulation development for screening of film coating properties that will shorten and simplify the development works.

• 出版日期2013-11-18