Anthocyanin Cyanidin-3-Glucoside Attenuates Platelet Granule Release in Mice Fed High-Fat Diets

作者：Zhou, Fang-Hang; Deng, Xiu-Juan; Chen, Yan-Qiu; Ya, Fu-Li; Zhang, Xian-Dan; Song, Fenglin; Li, Dan; Yang, Yan^*

来源：Journal of Nutritional Science and Vitaminology, 2017, 63(4): 237-243.

DOI：10.3177/jnsv.63.237

• anthocyanins
• platelet
• granule release
• cardiovascular diseases

Platelet granule release is considered an important target for preventing and treating cardiovascular diseases (CVDs). Cyanidin-3-glucoside (Cy-3-g) is a predominant bioactive anthocyanin compound in many edible plants and has been reported to be protective against CVDs by attenuating platelet dysfunction. However, direct evidence of the action of Cy-3-g on platelet granule secretion in purified platelets from in vivo assays is still poor. In the present study, we demonstrated that dietary supplementation of purified Cy-3-g reduces serum lipid levels and facilitates down-regulation of the platelet granule release of substances such as P-selectin, CD4OL, 5-HT, RANTES and TGF-beta 1 in gel-filtered platelets, in addition to attenuating serum PF4 and beta-TG levels in mice fed high-fat diets. These results provide evidence that Cy-3-g protects against thrombosis and CVDs by inhibiting purified platelet granule release in vivo.

• 出版日期2017-8
• 单位广州市妇女儿童医疗中心; 广东药科大学; 中山大学