Age-and sex-specific seasonal variation of venous thromboembolism in patients with and without family history: a nationwide family study in Sweden

作者：Zoller Bengt^*; Li Xinjun; Ohlsson Henrik; Sundquist Jan; Sundquist Kristina

来源：Thrombosis and Haemostasis, 2013, 110(6): 1164-1171.

DOI：10.1160/TH13-04-0320

• Venous thrombosis
• epidemiology
• seasons
• risk factors
• familial thrombosis

Seasonal variation in venous thromboembolism (VIE) risk in individuals with familial predisposition to VIE has not been explored. This nationwide study aimed to determine whether there are age- and sex-specific seasonal differences in risk of hospitalisation of VIE among individuals with and without a family history of VTE. The Swedish Multi-Generation Register was linked to Hospital Discharge Register data for the period 1964-2010. Seasonal Variation in first VTE events in 1987-2010 for individuals with and without a family history of VTE (siblings or parents) was determined by several independent methods. Stratified analyses were performed according to age, sex, and VTE Subtype (pulmonary embolism [PE] or deep venous thrombosis [DVT]). Seasonal variation in VIE incidence, Mostly With a peak during the winter, was observed in both sexes in individuals With and without family history with overall peak-to-low ratios (PLRs) of 1.15 and 1.21, respectively. The peak day was December 25 and February 1 for those with and without a family history of VTE, respectively. Seasonal variation Was strongest among individuals aged %26gt;50 years. Among individuals aged 0-25 years with a family history, the peak for VIE was in July (PLR = 1.20). Significant seasonal variation was observed for PE and DVT with the exception of DVT among those with a family history = (PLR = 1.01). In conclusion, our data support the presence of a modest seasonal variation of VIE among individuals with and without a family history of VIE. However, young age and family history may modify and attenuate the effect of season on VTE.

• 出版日期2013-12