Discovery and Total Synthesis of a New Estrogen Receptor Heterodimerizing Actinopolymorphol A from Actinopolymorpha rutilus

作者：Huang Sheng Xiong; Powell Emily; Rajski Scott R; Zhao Li Xing; Jiang Cheng Lin; Duan Yanwen; Xu Wei; Shen Ben^*

来源：Organic Letters, 2010, 12(15): 3525-3527.

DOI：10.1021/ol1013526

Estrogen receptor ER alpha and ER beta heterodimerization has been implicated in cancer chemoprevention. The discovery, structural elucidation, and total synthesis of a new natural product, actinopolymorphol A (1), from Actinopolymorpha rutilus (YIM45725) that preferentially induces ER alpha/beta heterodimerization is reported. Total synthesis of 1 has allowed us to determine Its absolute stereochemistry and that of a previously known deacetylated congener, and 1 represents the first member of a new class of natural products not previously recognized to modulate ER function.

• 出版日期2010-8-6
• 单位云南大学