Decreased selenium-binding protein 1 mRNA expression is associated with poor prognosis in renal cell carcinoma

作者：Ha Yun Sok; Lee Geun Taek; Kim Ye Hwan; Kwon Se Yun; Choi Seock Hwan; Kim Tae Hwan; Kwon Tae Gyun; Yun Seok Joong; Kim Isaac Yi; Kim Wun Jae^*

来源：World Journal of Surgical Oncology, 2014, 12(1): 288.

DOI：10.1186/1477-7819-12-288

• Renal cell carcinoma
• SELEMBP1
• Prognostic marker

Background: The anticancer effects of selenium may be mediated by selenium-binding proteins, such as SELENBP1. The association between SELENBP1 expression levels and clinicopathologic parameters was assessed in renal cell carcinoma (RCC). %26lt;br%26gt;Methods: SELENBP1 mRNA expression was measured with real-time quantitative polymerase chain reaction (qPCR) in 139 specimens of primary RCC and 59 specimens of donor-matched normal-appearing kidney tissues. The prognostic effect of SELENBP1 levels was evaluated with Kaplan-Meier and multivariate Cox regression analyses. %26lt;br%26gt;Results: SELENBP1 mRNA levels were significantly lower in tumor tissues than in matched normal kidney tissues (P %26lt; 0.001) and significantly inversely correlated with pathologic (T-stage and Fuhrman grade) and prognostic variables (progression and cancer-specific death). Kaplan-Meier estimates showed that low SELENBP1 expression was significantly correlated with cancer-specific death (log-rank test, P = 0.014), and a multivariate Cox regression model revealed that SELENBP1 expression was an independent predictor of cancer-specific death (HR, 0.111; P = 0.006). %26lt;br%26gt;Conclusions: SELENBP1 might play a role in tumor suppression and could be a useful prognostic factor in RCC.

• 出版日期2014-9-16
• 单位rutgers