科研之友
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摘要
We present a prototyped assay to detect glucose-6-phosphate dehydrogenase (G6PD) deficiency before administration of an anti-malaria drug, which may cause potentially lethal acute hemolytic anemia in patients with G6PD deficiency. The proton production from a chemical reaction catalyzed by G6PD was measured to reflect the G6PD activity in a blood sample. The device consists of a pH sensor, a temperature control unit, and a fluidic sample well, which were integrated on a print circuit board. The experimental results indicate that samples with G6PD deficiency can be diagnosed within 2 min rendering a point-of-care assay for rapid screening.
- 出版日期2015-9
