A photocleavable low molecular weight hydrogel for light-triggered drug delivery

作者：Liu, Qihong; Wang, Hao; Li, Guotao; Liu, Miaochang; Ding, Jinchang; Huang, Xiaobo; Gao, Wenxia^*; Wu, Huayue^*

来源：Chinese Chemical Letters, 2019, 30(2): 485-488.

DOI：10.1016/j.cclet.2018.06.009

• Low-molecular-weight hydrogelator
• Photocleavage
• Photo-triggered
• Drug delivery

A photocleavable low-molecular-weight hydrogelator (LMWG) was synthesized based on coumarin derivative. H-1 NMR and UV spectroscopy study suggested that the gelator had good gelling ability, and the driving force for the gelation were hydrogen bonding and pi-pi stacking. This molecular hydrogel exhibited satisfied photocleavage at C-N bond in 7-amino coumarin with the light irradiation (365 nm, 77.5 mW/cm(2)). The promising photo-triggered drug release of antineoplastics cytarabine hydrochloride has been obtained, due to the photocleavage motived gel-sol transition.

• 出版日期2019-2
• 单位温州大学