Assessment of HIV-1 Patient Recruitability in the Republic of Guinea-Bissau Using African versus North American Hematology and Biochemistry Reference Intervals

作者：Roman Victor Raul Gomez; Jensen Sanne Skov; Leo Hansen Christian; Jensen Kristoffer Jarlov; Janitzek Christoph Mikkel; Rodrigues Candida Medina; Jespersen Sanne; Katzenstein Terese Lea; Te David da Silva; Fomsgaard Anders^*

来源：Clinical and Vaccine Immunology, 2012, 19(8): 1322-1325.

DOI：10.1128/CVI.00170-12

Hematology and biochemistry reference intervals have been derived from healthy, HIV-negative populations to guide clinical trials worldwide. However, it is less clear how such values may be applied to clinical trials involving HIV-infected individuals. We show that contradictory interpretations about patient recruitability are reached when applying African versus North American reference intervals to an HIV-1 cohort in Guinea-Bissau. These observations underscore the need to question non-African guidelines in the context of HIV intervention clinical trials in Africa.