A clinically useful genetic variant in multiple sclerosis?

作者:Sellebjerg Finn*; Oturai Annette Bang
来源:Nature Reviews Neurology, 2015, 11(7): 371-+.
DOI:10.1038/nrneurol.2015.103

摘要

A recent study has identified a variant of the SLC9A9 gene that is associated with the clinical response to IFN-beta treatment. IFN-beta induces SLC9A9 expression, resulting in inhibition of proinflammatory T lymphocytes. The findings suggest a key role for this gene in determining the response to IFN-beta in patients with multiple sclerosis.

  • 出版日期2015-7

全文