科研之友
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摘要
Background Electrical impedance spectroscopy (EIS) is a noninvasive diagnostic technique that measures tissue impedance. Objectives To evaluate the effect of adding an EIS measurement at baseline to suspicious melanocytic lesions undergoing routine short-term sequential digital dermoscopy imaging (SDDI). Methods Patients presented with suspicious melanocytic lesions that were eligible for short-term SDDI (with no clear feature of melanoma on dermoscopy). EIS measurement was performed at the first visit following dermoscopic photography. Normally, an EIS score of >= 4 is considered positive; however, this protocol investigated a higher cut-off in combination with SDDI. When the EIS score was >= 7 the lesion was excised immediately owing to the high risk of melanoma. Lesions with a score <7 were monitored with standard SDDI over a 3-month period. Results From a total of 160 lesions analysed, 128 of 154 benign lesions received an EIS score of 0-6, giving a specificity of the EIS method for the diagnosis of melanoma of 83.1% [95% confidence interval (CI) 76.3-88.7]. Five of the six melanomas found in this study had an EIS score >= 7, with a sensitivity for melanoma diagnosis of 83.3% (95% CI 35.9-99.6). When EIS 0-6 lesions were subsequently followed up with SDDI, one additional melanoma was detected (EIS = 6) giving a sensitivity for the diagnosis of melanoma overall of 100% (95% CI 54.1-100; six of six malignant melanomas excised) and a specificity of 69.5% (95% CI 61.5-76.6; 107 of 154 benign lesions not excised). Conclusions If utilizing a protocol where an EIS score <= 3 requires no SDDI and >= 7 requires immediate excision, it reduced the need for SDDI by 46.9% (n = 75/160; 95% CI 39.0-54.9).
- 出版日期2017-11
