Diastereoselective alkynylation of N-p-tolylsulfinylimines with aluminum acetylides

作者：Turcaud Serge; Berhal Farouk; Royer Jacques^*

来源：Journal of Organic Chemistry, 2007, 72(21): 7893-7897.

DOI：10.1021/jo071139w

The addition of alkynyl dimethyl aluminum compounds onto N-p-tolylsulfinylimines was investigated. The reaction was proved to be totally regioselective, leading to propargylamines with high diastereoselectivity (up to 99% de). Addition of aluminum derivatives gave a reversal of diastereoselectivity compared to the addition reaction of lithium acetylide.

• 出版日期2007-10-12