Upregulated miR-106a plays an oncogenic role in pancreatic cancer

作者：Li Pei; Xu Qinhong; Zhang Dong; Li Xuqi; Han Liang; Lei Jianjun; Duan Wanxing; Ma Qingyong; Wu Zheng; Wang Zheng^*

来源：FEBS LETTERS, 2014, 588(5): 705-712.

DOI：10.1016/j.febslet.2014.01.007

• Pancreatic cancer
• miRNA
• miR-106a
• Cell invasion
• Tissue inhibitors of metalloproteinase 2

Carcinogenesis is a complex process during which cells undergo genetic and epigenetic alterations. MicroRNAs control gene expression by negatively regulating protein-coding mRNAs. Several reports demonstrated that miR-106a is up-regulated in gastric and colorectal cancers and promotes tumor progression. In contrast, in glioma miR-106a plays the role of a tumor suppressor gene rather than an oncogene. Here we demonstrate that a high level of miR-106a expression is present in pancreatic cancer. Furthermore, our investigation shows that miR-106a has an oncogenic role in pancreatic tumorigenesis by promoting cancer cell proliferation, epithelial-mesenchymal transition and invasion by targeting tissue inhibitors of metalloproteinase 2 (TIMP-2). MiR-106a could be a critical therapeutic target in pancreatic cancer.

• 出版日期2014-3-3
• 单位西安交通大学