Assessment of varicella vaccine effectiveness in Germany: a time-series approach

作者：Hoehle M^*; Siedler A; Bader H M; Ludwig M; Heininger U; Von Kries R

来源：Epidemiology and Infection, 2011, 139(11): 1710-1719.

DOI：10.1017/S0950268810002815

• GP surveillance systems
• infectious disease epidemiology
• statistics
• vaccines
• varicella zoster

A multivariate time-series regression model was developed in order to describe the 2005-2008 age-specific time-course of varicella sentinel surveillance data following the introduction of a varicella childhood vaccination programme in Germany. This ecological approach allows the assessment of vaccine effectiveness under field conditions by relating vaccine coverage in cohorts of 24-month-old children to the mean number of cases per reporting unit in the sentinel network. For the 1-2 years age group, which is directly affected by the vaccination programme, a one-dose vaccine effectiveness of 83.2% (95% CI 80.2-85.7) was estimated which corresponds to previous approaches assessing varicella vaccine effectiveness in the field in the USA.

• 出版日期2011-11