Apomorphine Effect on Pain Threshold in Parkinson's Disease: A Clinical and Positron Emission Tomography Study

作者：Dellapina Estelle^*; Gerdelat Mas Angelique; Ory Magne Fabienne; Pourcel Laure; Galitzky Monique; Calvas Fabienne; Simonetta Moreau Marion; Thalamas Claire; Payoux Pierre; Brefel Courbon Christine

来源：Movement Disorders, 2011, 26(1): 153-157.

DOI：10.1002/mds.23406

• Parkinson's disease
• pain threshold
• (H2O)-O-15 positron emission tomography
• apomorphine

Patients with Parkinson's disease (PD) frequently experience pain that could be in part due to central modification of nociception. In this randomized controlled double blind study, we compared the effect of apomorphine versus placebo on pain thresholds and pain- induced cerebral activity in 25 patients with PD. Subjective pain threshold (using thermal stimulation, thermotest), objective pain threshold (nociceptive flexion reflex), and cerebral activity ((H2O)-O-15 PET) during noxious and innocuous stimulations were performed. Neither subjective nor objective pain thresholds nor pain activation profile were modified by apomorphine compared with placebo in 25 PD patients. Apomorphine has no effect on pain processing in PD. We suggest that other monoamine systems than dopaminergic system could be involved.

• 出版日期2011-1