Phytosterols supplementation decreases plasma small and dense LDL levels in metabolic syndrome patients on a westernized type diet

作者：Sialvera T E; Pounis D; Koutelidakis A E; Richter D J; Yfanti G; Kapsokefalou M; Goumas G; Chiotinis N; Diamantopoulos E; Zampelas A^*

来源：Nutrition Metabolism and Cardiovascular Diseases, 2012, 22(10): 843-848.

DOI：10.1016/j.numecd.2010.12.004

• Phytosterols
• Small and dense LDL levels
• Metabolic syndrome

Background and aims: Several studies have observed a hypocholesterolemic effect of plant sterols in hypercholesterolemic patients on a balanced diet. The aim of this study was to examine the effect of phytosterol supplementation on risk factors of coronary artery disease in metabolic syndrome patients on a Westernized type diet. %26lt;br%26gt;Methods and results: In a randomized placebo-controlled design 108 patients with metabolic syndrome were assigned to consume either 2 plant sterol-enriched yogurt mini drink which provided 4 g phytosterols per day, or a yogurt beverage without phytosterols (control). The duration of the study was 2 months and the patients in both groups followed their habitual westernized type diet and recording it on food diaries. Blood samples were drawn at baseline and after 2 months of intervention. After 2 months supplementation with phytosterols, a significant reduction in total cholesterol, LDL-cholesterol, small and dense LDL (sdLDL) levels, as well as, apoB and triglycerides concentrations were observed in the intervention group (P %26lt; 0.05) compared to the control group. In addition, phytosterol supplementation lowered serum total cholesterol by 15.9%, LDL-cholesterol by 20.3% and triglyceride levels by 19.1% (P = 0.02, P %26lt; 0.001 and P %26lt; 0.001, respectively), although the patients kept their habitual westernized type diet. No differences were observed in HDL cholesterol, apoA1, glucose, C-reactive protein, fibrinogen levels and blood pressure. %26lt;br%26gt;Conclusions: Phytosterol supplementation improves risk factors of coronary artery disease even if the diet is a westernized type.

• 出版日期2012-10