A green, facile approach for the multicomponent synthesis of bioactive spiro[indoline-3,7′-pyrrolo[1,2-c]imidazole] derivatives

作者：Shen, Tianhua; Zhou, Yongbing; Che, Fengfeng; Yu, Jiangxia; Lin, Yan; Song, Qingbao^*

来源：Journal of Chemical Research, 2015, 39(2): 115-119.

DOI：10.3184/174751915X14229612721445

• spiro[indoline-3,7 '-pyrrolo[1,2-c]imidazole] derivatives
• water
• inhibitory activities
• multicomponent reaction

An efficient synthesis of spiro[indoline-3,7'-pyrrolo[1,2-c]imidazole] is achieved through a three-component reaction of isatins, malononitrile, and hydantoin/2-thiohydantoin in water catalysed by NaHCO3. All the target compounds were screened for the Cell Division Cycle 25 Phosphatase B (CDC25B) inhibitory activities.

• 出版日期2015-2
• 单位浙江工业大学