科研之友
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摘要
An enantioselective multicomponent carbonyl allylation reaction of 1,3-butadienes, alkynyl bromides and aldehydes has been established, leading to the generation of densely functionalized homoallylic alcohols in high levels of structural diversity and stereoselectivity. The multicomponent process sequentially comprises the oxidative addition, salt metathesis, insertion/pi-allyl-Pd formation, asymmetric allylic borylation, and enantioslecitve carbonyl allylborylation, wherein the alkynyl palladium phosphate in situ generated from the chiral silver phosphate and the alkynyl palladium bromide turns out to be a key intermediate that allows the efficient stereochemical control.
- 出版日期2017-7-17
- 单位中国科学技术大学
