Mannich-type reactions of aromatic aldehydes, anilines, and methyl ketones in fluorous biphase systems created by rare earth (III) perfluorooctane sulfonates catalysts in fluorous media

作者：Yi Wen Bin; Cai Chun^*

来源：Journal of Fluorine Chemistry, 2006, 127(11): 1515-1521.

DOI：10.1016/j.jfluchem.2006.07.009

• mannich reaction
• fluorous biphasic catalysis
• rare earth (III) perfluorooctanesulfonates
• perfluorocarbon

Rare earth (III) perfluorooctane sulfonates (RE(OPf)(3)) catalyze the three-component Mannich-type reactions of different ketones with various aromatic aldehydes and aromatic amines in fluorous media to give various beta-arylamino ketones in good yields. By simple separation of the fluorous phase containing only catalyst, reaction can be repeated several times.

• 出版日期2006-11
• 单位南京大学