A flexible loop-type flow modulator for comprehensive two-dimensional gas chromatography

作者：Tranchida Peter Quinto; Purcaro Giorgia; Visco Alessandro; Conte Lanfranco; Dugo Paola; Dawes Peter; Mondello Luigi^*

来源：Journal of Chromatography A, 2011, 1218(21): 3140-3145.

DOI：10.1016/j.chroma.2010.11.082

• Flow modulation
• Comprehensive two-dimensional gas chromatography
• GC x GC
• Food analysis
• Flow splitting

The present investigation is focused on a simple flow modulator (FM), for comprehensive two-dimensional gas chromatography (GC x GC). The interface is stable at high temperatures, and consists of a metallic disc (located inside the GC oven) with seven ports, which are connected to an auxiliary pressure source via two branches, to the first and second dimension, to a waste branch (linked to a needle valve) and to an exchangeable modulation loop (2 ports). The ports are connected via micro-channels, etched on one of the inner surfaces of the disc. Modulation is achieved using a two-way electrovalve, connected on one side to the additional pressure source, and to the two metal branches, on the other. An FM enantio-GC x polar-GC method (using a flame ionization detector) was optimized (a 40-mu L loop was employed), for the analysis of essential oils. As an example, an application on spearmint oil is shown; the method herein proposed was subjected to validation. Finally, an FM GC x GC diesel experiment was carried out, using an apolar-polar column combination, to demonstrate the effectiveness of the modulator in the analysis of a totally different sample-type.

• 出版日期2011-5-27