Application of chemometric assisted dispersive liquid-liquid microextraction to the determination of personal care products in natural waters

作者：Panagiotou Aikaterini N; Sakkas Vasilios A^*; Albanis Triantafyllos A

来源：Analytica Chimica Acta, 2009, 649(2): 135-140.

DOI：10.1016/j.aca.2009.07.028

• Experimental design
• Response surface methodology
• Phthalic acid esters
• Polycyclic musks

A rapid and simple method for the determination of two phthalates and five polycyclic musks in water samples using dispersive liquid-liquid microextraction (DLLME) mated to chemometrics and coupled to GC-MS was developed. Volume of extraction (CCl(4)) and disperser solvent (MeOH), pH, ionic strength, extraction time, centrifugation time as well as centrifugation speed were optimized in a 2(7-4) Plackett-Burman design. The obtained significant factors were optimized by using a central composite design (CCD) and the quadratic model between the dependent and the independent variables was built. The optimum experimental conditions of the proposed method were: 250 mu L, carbon tetrachloride, 0.62 ml, methanol, 7.5 min centrifugation time, natural pH containing 0% (w/v) NaCl, while keeping centrifugation speed fixed at 4000 rpm.
The calculated calibration curves gave high-level linearity for all target analytes with correlation coefficients ranging between 0.9970 and 0.9992. The repeatability and reproducibility of the proposed method, expressed as relative standard deviation, varied between 2.6% to 9.7% and 5.7% to 12.2%, respectively. The obtained LOD values were in the range of 8-63 ng L(-1).

• 出版日期2009-9-7