Deletion variant of alpha 2b-adrenergic receptor gene moderates the effect of COMT val(158)met polymorphism on episodic memory performance

作者：Gibbs Ayana A^*; Naudts Kris H; Azevedo Ruben T; David Anthony S

来源：European Neuropsychopharmacology, 2010, 20(4): 272-275.

DOI：10.1016/j.euroneuro.2009.12.007

• Genetics
• Emotional memory
• Episodic memory
• COMT
• ADRA2B
• Catecholamines
• Noradrenaline

The COMT val(158) variant has been associated with impaired cognitive function compared to the Met(158) variant yet gene gene interactions are not well described. In this study we demonstrate an interaction between this COMT polymorphism and a deletion variant of ADRA2B, the gene encoding the alpha 2b-adrenergic receptor on episodic memory performance. Specifically, carriage of the ADRA2B deletion abolished the relative memory impairment in homozygous COMT val(158) carriers compared to Met(158) carriers.

• 出版日期2010-4