alpha-Glucosidase Inhibitory, Aromatase Inhibitory, and Antiplasmodial Activities of a Biflavonoid GB1 from Garcinia kola Stem Bark

Antia Bassey S; Pansanit Acharavadee; Ekpa Okon D; Ekpe Udofot J; Mahidol Chulabhorn; Kittakoop Prasat<sup>*</sup>

doi:10.1055/s-0029-1186081

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alpha-Glucosidase Inhibitory, Aromatase Inhibitory, and Antiplasmodial Activities of a Biflavonoid GB1 from Garcinia kola Stem Bark

作者：Antia Bassey S; Pansanit Acharavadee; Ekpa Okon D; Ekpe Udofot J; Mahidol Chulabhorn; Kittakoop Prasat^*

来源：Planta Medica, 2010, 76(3): 276-277.

DOI：10.1055/s-0029-1186081

摘要

The biflavonoid, 3 '',4',4''',5,5 '',7,7 ''-heptahydroxy-3,8-biflavanone, known as GB1 (1), was isolated as amajor constituent from Garcinia kola stem bark. GB1 (1) exhibited alpha-glucosidase and aromatase inhibitory activities, as well as antiplasmodial activity, but was not toxic against cell lines tested. GB1 (1) may be a potential dietary supplement or phytomedicine for the prevention of breast cancer and type 2 diabetes mellitus.