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摘要
<jats:p>In the eukaryotic nucleus, <jats:styled-content style="fixed-case">RNA</jats:styled-content>‐binding proteins (<jats:styled-content style="fixed-case">RBPs</jats:styled-content>) play a very important role in the life cycle of both coding and noncoding <jats:styled-content style="fixed-case">RNAs</jats:styled-content>. As soon as they are transcribed, in fact, all <jats:styled-content style="fixed-case">RNA</jats:styled-content> molecules within a cell are bound by distinct sets of <jats:styled-content style="fixed-case">RBPs</jats:styled-content> that have the task of regulating its correct processing, transport, stability, and function/translation up to its final degradation. These tasks are particularly important in cells that have a complex <jats:styled-content style="fixed-case">RNA</jats:styled-content> metabolism, such as neurons. Not surprisingly, therefore, recent findings have shown that the misregulation of genes involved in <jats:styled-content style="fixed-case">RNA</jats:styled-content> metabolism or the autophagy/proteasome pathway plays an important role in the onset and progression of several neurodegenerative diseases. In this article, we aim to review the recent advances that link neurodegenerative processes and <jats:styled-content style="fixed-case">RBP</jats:styled-content> proteins. <jats:italic>WIREs RNA</jats:italic> 2017, 8:e1394. doi: 10.1002/wrna.1394</jats:p><jats:p>This article is categorized under: <jats:list list-type="explicit-label"> <jats:list-item><jats:p>RNA Interactions with Proteins and Other Molecules > RNA–Protein Complexes</jats:p></jats:list-item> <jats:list-item><jats:p>RNA Processing > Splicing Regulation/Alternative Splicing</jats:p></jats:list-item> <jats:list-item><jats:p>RNA in Disease and Development > RNA in Disease</jats:p></jats:list-item> </jats:list></jats:p>
- 出版日期2017-4
