Urinary monocyte chemoattractant protein-1 correlates with disease activity in lupus nephritis

作者：Marks Stephen D^*; Shah Vanita; Pilkington Clarissa; Tullus Kjell

来源：Pediatric Nephrology, 2010, 25(11): 2283-2288.

DOI：10.1007/s00467-010-1605-z

• Systemic lupus erythematosus
• Lupus nephritis
• Pediatric
• Biomarkers
• MCP-1 (monocyte chemoattractant protein-1)

Monocyte chemoattractant protein-1 (MCP-1) has a pathogenic role in murine lupus nephritis (LN). We recruited 25 pediatric and adolescent systemic lupus erythematosus (SLE) patients from our lupus clinic [13 (52%) patients with LN and 12 (48%) lupus non-nephritis patients] and evaluated their urinary and plasma MCP-1 levels compared to adult and childhood controls. The median age and SLE disease duration of patients were 14.4 and 5.5 years, respectively. LN patients had a higher median renal (p = 0.01) British Isles Lupus Assessment Group (BILAG) index, with a tendency for higher total BILAG scores (p = 0.2). There were significantly increased urinary MCP-1 levels in the LN patients compared to healthy controls (p < 0.001) whose values were significantly higher than lupus non-nephritis children (p < 0.004). Urinary MCP-1 levels correlated well with total BILAG scores (r = 0.82, p = 0.04). There were no differences in plasma MCP-1 levels between SLE patient groups and pediatric controls, although the levels in the childhood controls were elevated compared to those of the adult controls (p < 0.04). These results provide evidence of increased urinary-but not plasma-MCP-1 levels in children with LN, which correlates well with SLE disease activity as measured by the BILAG index.

• 出版日期2010-11