An Alternative Stereoselective Total Synthesis of (+)-Cephalosporolide D

作者：Murthy Indraganti Sreenivasa; Sreenivasulu Reddymasu; Alluraiah Gurrala; Raju Rudraraju Ramesh^*

来源：Letters in Organic Chemistry, 2014, 11(5): 327-332.

DOI：10.2174/1570178611666140124001937

• (+)-Cephalosporolide D
• L - Proline catalyzed reaction
• (+/-)-Propylene epoxide
• stereoselective synthesis
• total synthesis and Yamaguchi macrolactonization

An efficient stereoselective total synthesis of (+)-Cephalosporolide D from commercially available and inexpensive starting material, (+/-)-propylene epoxide, is described. The key steps involved in this synthesis are alpha-aminoxylation catalyzed by L-proline, followed by in situ reduction using NaBH4 and Yamaguchi macrolactonization.

• 出版日期2014