New Pharmacologic Therapies in Chronic Hepatitis B

作者：Hongthanakorn Chanunta^*; Lok Anna S F

来源：Gastroenterology Clinics of North America, 2010, 39(3): 659-+.

DOI：10.1016/j.gtc.2010.08.012

• Hepatitis B virus
• Interferon
• Nucleos(t)ide analogue
• Entecavir
• Tenofovir

Approximately 350 million persons worldwide are chronically infected with hepatitis B which can result in cirrhosis, liver failure and hepatocellular carcinoma Currently 2 interferons and 5 nucleos(t)ide analogues have been approved for the treatment of chronic hepatitis B (CHB) This article discusses the mechanisms of action pharmacokinetics optimal dose clinical efficacy, and side effects of medications used for the treatment of CHB

• 出版日期2010-9