Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth

作者：Kubinova Renata; Porizkova Radka; Navratilova Alice; Farsa Oldrich; Hanakova Zuzana; Bacinska Adriana; Cizek Alois; Valentova Marie^*

来源：Journal of Enzyme Inhibition and Medicinal Chemistry, 2014, 29(5): 749-752.

DOI：10.3109/14756366.2013.848204

• alpha-glucosidase
• antibacterial activity
• cholinesterase
• diterpenoids
• rosmarinic acid

Plectranthus madagascariensis is used as a traditional medicine in Southern Africa. In search of compounds and activities supporting the medicinal use, the chemical profile of the methanolic extract was studied by high-performance liquid chromatography with diode array detection (HPLC-DAD). Four major constituents were isolated and identified as rosmarinic acid (1), 7 beta, 6 beta-dihydroxyroyleanone (2), 7 beta-acetoxy-6 beta-hydroxyroyleanone (3) and coleon U quinone (4). The two abietane diterpenoids (2 and 3) were isolated for the first time from this species. Antimicrobial, cholinesterase and alpha-glucosidase inhibitory activities of these compounds were studied. The compounds exhibited inhibitory activity on alpha-glucosidase with IC50 values from 33 to 275 mu M. Abietanes showed potent antibacterial activity against Staphylococcus aureus and Enterococcus faecalis.

• 出版日期2014-10