Marked Reduction in Serotonergic Activity in a Sexually Aggressive Adolescent Male

作者：Kumar Adarsh M^*; Kumar Mahendra; Lahey Benjamin B; Katz Debra A; Fernandez Benny; Shaw Jon A; Campo Ana; Nemeroff Charles B

来源：Journal of Neuropsychiatry and Clinical Neurosciences, 2014, 26(3): 262-270.

DOI：10.1176/appi.neuropsych.13060138

Serotonergic dysfunctions are implicated in conduct disorder, impulsivity, and aggression. Early adverse experiences increase the risk for these behaviors in adolescents. The authors investigated serotonergic activity in one adolescent male who experienced maternal abandonment and childhood abuse and exhibited severely aggressive sexual offenses. Platelet serotonin (5-HT) concentration, [C-14]-5HT uptake kinetics, and plasma prolactin, cortisol response to D, L-fenfluramine (D, L-FEN) were measured. Results showed extremely low 5-HT concentration (2.9 +/- 0.7 ng/10(8) platelets), [C-14]-5HT uptake rate (0.5 +/- 0.04 mu M/min/10(7)platelets), undetectable K-m and V-max, and abnormally blunted prolactin, cortisol response to D, L-FEN. These abnormalities in this sexually aggressive adolescent may be a consequence of childhood abuse.

• 出版日期2014