ER Stress Promotes Inflammation through Re-wIREd Macrophages in Obesity

作者:Garfinkel Benjamin P; Hotamisligil Gokhan S
来源:Molecular Cell, 2017, 66(6): 731-733.
DOI:10.1016/j.molcel.2017.05.037

摘要

A new mechanism linking ER dysfunction to metabolic inflammation is discovered in a recent study by Shan et al. (2017), which demonstrated ER stress-induced rewiring of adipose tissue macrophage polarization by IRE1 alpha activation, leading to impaired systemic glucose homeostasis.

  • 出版日期2017-6-15