科研之友
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摘要
Background: The aim of this study was to observe the association between fibrinogen C148T, G854A polymorphisms and plasma fibrinogen levels in a large cohort of Chinese patients with coronary heart disease (CHD). Methods: Fibrinogen gene beta 148/beta 854 polymorphisms were screened and plasma fibrinogen levels and lipids were measured in patients with angiographically confirmed CHD (n = 836) and in controls without CHD ( n = 418). Results: Age, sex, smoking, hypertension, diabetes mellitus, blood lipids and fibrinogen levels were related to CHD (all p < 0.05)while the frequencies of fibrinogen beta 148 and beta 854 alleles, gene and genotypes between the two groups were similar (all p > 0.05). Conclusion: This study demonstrates that the plasma fibrinogen level, but not fibrinogen beta 148 and beta 854 genotypes, was associated with CHD in the Chinese population.
- 出版日期2008
- 单位上海交通大学; 复旦大学; 中国中医科学院; 中国中医科学院广安门医院; 中国人民解放军第二炮兵总医院; 上海市闵行区中心医院
