A Facile BPO-Mediated ortho-Hydroxylation and Benzoylation of N-Alkyl Anilines for Synthesis of 2-Benzamidophenols

作者:Zhang Zhi Jing; Quan Xue Jing; Ren Zhi Hui; Wang Yao Yu; Guan Zheng Hui*
来源:Organic Letters, 2014, 16(12): 3292-3295.
DOI:10.1021/ol501293c

摘要

A facile benzoyl peroxide (BPO) mediated ortho-hydroxylation and benzoylation of N-alkyl anilines for the synthesis of 2-benzamidophenols has been developed. The reaction tolerates a wide range of functional groups and is a good method for the straightforward synthesis of valuable 2-benzamidophenols in good yields under mild conditions.