Two different types of infantile renal cell carcinomas associated with tuberous sclerosis

作者：Kubo Masako^*; Iwashita Kimie; Oyachi Noboru; Oyama Toshio; Yamamoto Toshiyuki

来源：Journal of Pediatric Surgery, 2011, 46(10): E37-E41.

DOI：10.1016/j.jpedsurg.2011.06.035

• Tuberous sclerosis
• Renal cell carcinoma
• TSC2

Renal cell carcinoma (RCC) associated with tuberous sclerosis (TSC) has been reported in adult patients; however, this association is rare in children. We have encountered 2 different types of RCCs in infants who developed TSC later in childhood. The pathologic diagnoses were papillary RCC in one infant and a clear cell-type RCC in the other. Gene analysis showed that both the patients had a mutation in TSC2 gene on chromosome 16.

• 出版日期2011-10