Doubly robust estimation, optimally truncated inverse-intensity weighting and increment-based methods for the analysis of irregularly observed longitudinal data

作者：Pullenayegum Eleanor M^*; Feldman Brian M

来源：Statistics in Medicine, 2013, 32(6): 1054-1072.

DOI：10.1002/sim.5640

• longitudinal data
• inverse-probability weighting
• doubly robust estimation

Longitudinal data arising from routine follow-up of patients will often have irregular measurement times. Existing methods for analysis include joint modelling of the outcome and measurement processes, and inverse-intensity weighting (IIW). This work extends previously proposed analysis of increments to the case of irregular follow-up, yielding a model for the increments that can be used as a stand-alone method. Furthermore, we propose two ways of combining the increments and IIW estimators. First, we use the increment model to select the truncation point for the inverse-intensity weights that minimises the mean squared error of the IIW estimator. Second, we use the increment model to augment the usual IIW estimating equations to form a doubly robust estimator. We evaluate the methods through simulation and apply these to a recent study of juvenile dermatomyositis.

• 出版日期2013-3-15