Applied Enantioselective Aminocatalysis: alpha-Heteroatom Functionalization Reactions on the Carbapenem (beta-Lactam Antibiotic) Core

作者：Cele Zamani E D; Arvidsson Per I; Kruger Hendrik G; Govender Thavendran^*; Naicker Tricia

来源：European Journal of Organic Chemistry, 2015, 2015(3): 638-646.

DOI：10.1002/ejoc.201403238

• Lactams
• Nitrogen heterocycles
• Amino acids
• Organocatalysis
• Synthetic methodology

The carbapenem (beta-lactam antibiotic) scaffold serves as a useful nucleophile in organocatalytic diarylprolinol trimethylsilyl ether mediated alpha-heterofunctionalization reactions leading to the formation of diverse products that bear multiple stereocenters in high diastereoselectivity and moderate to good yields.

• 出版日期2015-1