Anti-granulocyte scintigraphy in early rheumatoid arthritis - does it work?

作者：Horkay Edit; Kincse Gyoengyver; Varga Jozsef; Szabados Lajos; Garai Ildiko; Gaal Janos^*

来源：Central European Journal of Medicine, 2013, 8(5): 558-564.

DOI：10.2478/s11536-013-0203-4

• Prediction of erosiveness
• Leukocyte accumulation
• MRI
• Anti-granulocyte scintigraphy
• Anti-CCP positivity

To compare the performance of anti-granulocyte scintigraphy with those of widely used prognostic indices (such as DAS28, anti-CCP, early MRI imaging). %26lt;br%26gt;Twenty-five patients with early arthritis were enrolled into the study. Following the review of clinical data and the evaluation of disease activity, we performed MRI imaging of the hands, anti-granulocyte scintigraphy, and determined anti-CCP positivity. The relationship between the changes of MRI scores and the above prognostic factors were analyzed statistically. %26lt;br%26gt;At baseline, values were as follows: DAS28 3.86 +/- 1.19, CRI 0.15 +/- 0.12, MRI erosions and synovitis scores 25.11 +/- 12.82 and 4.32 +/- 4.02 (respectively), the ratio of anti-CCP positivity was 7/12 (58%). After the follow-up period of 13.6 +/- 2.52 months, erosion and synovitis scores were 43.11 +/- 22.23, and 5.32 +/- 6.16, respectively (p=0,001 and p=0,015). The occurrence of new erosions was correlated with baseline erosion score (k=0.523, p=0.022) and anti-CCP positivity (p=0.021). The relationship between CRI and baseline synovitis score was strong (=0.518, p=0.023), whereas it was weak only between the former and baseline erosion score (=0.402, p=0.08). %26lt;br%26gt;As shown by this study, potential markers for predicting subsequent destructiveness in early RA include MRI and anti-CCP testing, primarily. 99mTc labeled anti-granulocyte joint scintigraphy is appropriate for the objective and quantitative appraisal of disease activity.

• 出版日期2013-10