An isoindole alkaloid from Portulaca oleracea L.

作者：Jiang, Mingyue; Zhang, Wenjie; Yang, Xu; Xiu, Fen; Xu, Haoran; Ying, Xixiang^*; Stien, Didier^*

来源：Natural Product Research, 2018, 32(20): 2431-2436.

DOI：10.1080/14786419.2017.1419226

• Portulaca oleracea L.
• alkaloid
• nitric oxide (NO)

A novel isoindole alkaloid named oleraisoindole (1), together with six known compounds, 7'-ethoxy-trans-feruloyltyramine (2), N-transferuloyltyramine (3), N-trans-feruloyl-3-methoxytyramine (4), N-transp- coumaroyltyramine (5) aurantiamide (6) and ferulic acid methyl ester (7) were isolated from Portulaca oleracea L. Compounds 2 and 7 were isolated for the first time from this plant. Compound 1 was identified using spectroscopic methods including HR-ESI-TOF-MS, 1D-NMR, 2D-NMR. It was tested in a nitric oxide (NO) inhibition assay and was shown to inhibit NO production in RAW 264.7 cells induced by LPS.
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• 出版日期2018-10-18
• 单位辽宁中医药大学