Gender differences in the effects of methylphenidate on energy intake in young adults: a preliminary study

作者：Goldfield Gary S^*; Lorello Claudio; Cameron Jameason; Chaput Jean Philippe

来源：Applied Physiology Nutrition and Metabolism, 2011, 36(6): 1009-1013.

DOI：10.1139/H11-098

• gender
• methylphenidate
• dopamine
• eating
• energy intake
• food reinforcement
• obesity

The present study examined gender differences in response to methylphenidate (MPH) on energy intake and macronutrient preference. Twelve adults (6 men, 6 women) were given placebo or short-acting MPH (0.5 mg/kg) in a randomized, double blind, placebo-controlled crossover fashion. One hour after drug administration, appetite sensations and the relative reinforcing value of energy-dense snack food were measured, followed immediately by energy intake and macronutrient preference during a buffet lunch. Relative to placebo, men exhibited a significantly greater reduction in energy intake, fat intake, and carbohydrate intake after MPH administration compared with women. Future research is needed to verify these initial findings.

• 出版日期2011-12