Alkaloids from Lycoris caldwellii and their particular cytotoxicities against the astrocytoma and glioma cell lines

作者：Cao, Peng; Pan, Dong-Sheng; Han, Song; Yu, Chun-Yong; Zhao, Qing-Jie; Song, Yan; Liang, Yong^*

来源：Archives of Pharmacal Research, 2013, 36(8): 927-932.

DOI：10.1007/s12272-013-0089-3

• Lycoris caldwellii
• Amaryllidaceae
• Alkaloids
• Cytotoxicity

Phytochemical investigation of the ethanol extract of the bulbs of Lycoris caldwellii afforded four new alkaloids, (+)-N-methoxylcarbonyl-nandigerine (1), (+)-N-methoxycarbonyl-lindcarpine (2), (+)-10-O-methylhernovine N-oxide (3), and (+)-3-hydroxy-anhydrolycorine N-oxide (4). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (H-1-H-1 COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. All the alkaloids were in vitro evaluated for their cytotoxic activities against eight tumor cell lines (BEN-MEN-1, CCF-STTG1, CHG-5, SHG-44, U251, BGC-823, HepG2, and SK-OV-3). Alkaloids 1 and 2 exhibited particular cytotoxic activities against astrocytoma and glioma cell lines with IC50 of 9.2-11.3 mu M and 10.4-12.2 mu M respectively.

• 出版日期2013-8
• 单位中国人民解放军沈阳军区总医院; 中国人民解放军第四五五医院; 中国人民解放军第二军医大学