Anti-HIV-1 activities of extracts and phenolics from Smilax china L.

作者：Wang, Wei-Xin; Qian, Jing-Yi; Wang, Xiao-Jing; Jiang, Ai-Ping; Jia, Ai-Qun^*

来源：Pakistan Journal of Pharmaceutical Sciences, 2014, 27(1): 147-151.

• Smilax china L.
• phenolics
• TZMB-L cells
• anti-HIV-1
• pseudotyped virus
• structure-activity relationship

Four extracts (EtOH, CHCl3, EtOAc, and BuOH) and five phenolics (dihydrokaempferol (1), resveratrol (2), kaempferol-7-O-beta-D-glucoside (3), dihydrokaempferol-3-O-alpha-L-rhamnoside (4), oxyresveratrol (5)) from Smilax china L. was evaluated for anti-HIV-1 activities and cytotoxicity activities in vitro. All these extracts and phenolics showed lower or no cytotoxicity at a concentration ranged from 0.8 mu g/mL to 100 mu g/mL, but some showed potential anti-HIV-1 activities, that is, BuOH extract and compound 2 showed higher anti-HIV-1 activities than other extracts and compounds in the tested concentrations. EtOAc extract and compound 1 and 3 showed moderate anti-HIV-1 activities at a concentration higher than 4 mu g/mL. In the end, the structure-activity relationship of four extracts and five phenolics was discussed.

• 出版日期2014-1
• 单位中国科学院上海巴斯德研究所; 南京理工大学